Sparstolonin B attenuates early liver inflammation in experimental NASH by modulating TLR4 trafficking in lipid rafts via NADPH oxidase activation
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منابع مشابه
Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation.
Endotoxin tolerance is characterized by attenuated macrophage activation to subsequent LPS challenge and can be reversed through nonspecific protein kinase C (PKC) activation, and activation by LPS within naïve cells requires the activation of the cell surface receptors CD14 and TLR4 on lipid rafts. The effect of PKC activation and endotoxin tolerance on lipid raft receptor complex assembly is ...
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Oxidative stress has emerged as an important pathogenic factor in the development of breast cancer. Cholesterol-rich membrane rafts or lipid rafts (LRs) are reported to play an important role in oxidative stress-induced signal transduction. NADPH oxidase-dependent reactive oxygen species (ROS) production is implicated in oxidative stress in human mammary epithelial cells. In the present study, ...
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Yongzhong Wei, James R. Sowers, Suzanne E. Clark, Wenhan Li, Carlos M. Ferrario, and Craig S. Stump Department of Internal Medicine, University of Missouri-Columbia; Harry S. Truman Memorial Veterans Affairs Medical Center, Columbia, Missouri; Wake Forest University School of Medicine, Winston-Salem, North Carolina; Diabetes Research Program, Department of Medicine, University of Arizona; and S...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Gastrointestinal and Liver Physiology
سال: 2016
ISSN: 0193-1857,1522-1547
DOI: 10.1152/ajpgi.00259.2015